TOol for Motif TO Motif comparison (TOMTOM)

For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net.

If you use TOMTOM in your research, please cite the following paper:
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.

Query Motifs  |  Target Databases  |  Matches  |  Program information  |  Explanation

Query Motifs

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Name 

Preview 

Matches 

List 

HGATAA
AGATAA
5 MA0036.2 (GATA2),  MA0482.1 (Gata4),  MA0035.3 (Gata1),  MA0140.2 (TAL1::GATA1),  MA0037.2 (GATA3)
CAKCTGB
CATCTGC
6 MA0091.1 (TAL1::TCF3),  MA0461.1 (Atoh1),  MA0521.1 (Tcf12),  MA0500.1 (Myog),  MA0499.1 (Myod1),  MA0522.1 (Tcf3)
AGATA
AGATA
0
CCMCASCC
CCCCACCC
3 MA0039.2 (Klf4),  MA0493.1 (Klf1),  MA0599.1 (KLF5)
CACAG
CACAG
1 MA0332.1 (MET28)
SAGRAA
CAGGAA
1 MA0598.1 (EHF)
BTTCCC
CTTCCC
1 MA0470.1 (E2F4)
GGATAAGM
GGATAAGA
0
GVCTGATA
GGCTGATA
0
GCCTGB
GCCTGG
0
BAGATTA
GAGATTA
0

Target Databases

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Database 

Number of Motifs 

Motifs Matched 

JASPAR_CORE_2014.meme 593 17

Matches to Query: HGATAA

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Summary 

Alignment 

Name MA0036.2
Alt. Name GATA2
Database JASPAR_CORE_2014.meme
p-value 2.95078e-06
E-value 0.00174981
q-value 0.00348459
Overlap 6
Offset 2
Orientation Reverse Complement
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Summary 

Alignment 

Name MA0482.1
Alt. Name Gata4
Database JASPAR_CORE_2014.meme
p-value 1.0702e-05
E-value 0.00634631
q-value 0.00631904
Overlap 6
Offset 3
Orientation Reverse Complement
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Summary 

Alignment 

Name MA0035.3
Alt. Name Gata1
Database JASPAR_CORE_2014.meme
p-value 2.58091e-05
E-value 0.0153048
q-value 0.0101594
Overlap 6
Offset 2
Orientation Reverse Complement
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Summary 

Alignment 

Name MA0140.2
Alt. Name TAL1::GATA1
Database JASPAR_CORE_2014.meme
p-value 3.72938e-05
E-value 0.0221152
q-value 0.0110101
Overlap 6
Offset 11
Orientation Reverse Complement
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Summary 

Alignment 

Name MA0037.2
Alt. Name GATA3
Database JASPAR_CORE_2014.meme
p-value 5.58385e-05
E-value 0.0331122
q-value 0.013188
Overlap 6
Offset 0
Orientation Normal
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Matches to Query: CAKCTGB

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Summary 

Alignment 

Name MA0091.1
Alt. Name TAL1::TCF3
Database JASPAR_CORE_2014.meme
p-value 8.93223e-06
E-value 0.00529681
q-value 0.0096193
Overlap 7
Offset 4
Orientation Normal
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Summary 

Alignment 

Name MA0461.1
Alt. Name Atoh1
Database JASPAR_CORE_2014.meme
p-value 1.6389e-05
E-value 0.00971871
q-value 0.0096193
Overlap 6
Offset 2
Orientation Reverse Complement
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Summary 

Alignment 

Name MA0521.1
Alt. Name Tcf12
Database JASPAR_CORE_2014.meme
p-value 3.36028e-05
E-value 0.0199264
q-value 0.0119154
Overlap 7
Offset 2
Orientation Normal
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Summary 

Alignment 

Name MA0500.1
Alt. Name Myog
Database JASPAR_CORE_2014.meme
p-value 4.0602e-05
E-value 0.024077
q-value 0.0119154
Overlap 7
Offset 2
Orientation Normal
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Summary 

Alignment 

Name MA0499.1
Alt. Name Myod1
Database JASPAR_CORE_2014.meme
p-value 6.79865e-05
E-value 0.040316
q-value 0.0146059
Overlap 7
Offset 5
Orientation Reverse Complement
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Summary 

Alignment 

Name MA0522.1
Alt. Name Tcf3
Database JASPAR_CORE_2014.meme
p-value 8.03202e-05
E-value 0.0476299
q-value 0.0146059
Overlap 7
Offset 3
Orientation Reverse Complement
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Matches to Query: AGATA

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Matches to Query: CCMCASCC

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Summary 

Alignment 

Name MA0039.2
Alt. Name Klf4
Database JASPAR_CORE_2014.meme
p-value 6.94438e-06
E-value 0.00411802
q-value 0.00704971
Overlap 8
Offset 1
Orientation Reverse Complement
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Summary 

Alignment 

Name MA0493.1
Alt. Name Klf1
Database JASPAR_CORE_2014.meme
p-value 1.46331e-05
E-value 0.00867744
q-value 0.00704971
Overlap 8
Offset 2
Orientation Normal
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Summary 

Alignment 

Name MA0599.1
Alt. Name KLF5
Database JASPAR_CORE_2014.meme
p-value 1.8063e-05
E-value 0.0107114
q-value 0.00704971
Overlap 8
Offset 1
Orientation Normal
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Matches to Query: CACAG

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Summary 

Alignment 

Name MA0332.1
Alt. Name MET28
Database JASPAR_CORE_2014.meme
p-value 3.73208e-05
E-value 0.0221312
q-value 0.0442625
Overlap 5
Offset 1
Orientation Reverse Complement
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Matches to Query: SAGRAA

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Summary 

Alignment 

Name MA0598.1
Alt. Name EHF
Database JASPAR_CORE_2014.meme
p-value 3.61533e-05
E-value 0.0214389
q-value 0.0427299
Overlap 6
Offset 0
Orientation Reverse Complement
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Matches to Query: BTTCCC

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Summary 

Alignment 

Name MA0470.1
Alt. Name E2F4
Database JASPAR_CORE_2014.meme
p-value 6.28647e-05
E-value 0.0372788
q-value 0.0575619
Overlap 6
Offset 1
Orientation Reverse Complement
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Matches to Query: GGATAAGM

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Matches to Query: GVCTGATA

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Matches to Query: GCCTGB

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Matches to Query: BAGATTA

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TOMTOM version
4.9.0 (Release date: Wed Oct 3 11:07:26 EST 2012)
Reference
Shobhit Gupta, JA Stamatoyannopolous, Timothy Bailey and William Stafford Noble, "Quantifying similarity between motifs", Genome Biology, 8(2):R24, 2007.
Command line summary

Background letter frequencies (from first motif database):
A: 0.250   C: 0.250   G: 0.250   T: 0.250

Result calculation took 2.354 seconds
show model parameters...

Explanation of TOMTOM Results

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The TOMTOM results consist of

Inputs

The important inputs to TOMTOM.

Query Motifs

The query motifs section lists the motifs that were searched for in the target databases as well as links to matches found.

Name
The motif name.
Alt. Name
The alternative motif name. This column may be hidden if no query motifs have an alternate name.
Website
A link to a website which has more information on the motif. This column may be hidden if no query motifs have website information.
Preview
The motif preview. On supporting browsers this will display as a motif logo, otherwise the consensus sequence will be displayed.
Matches
The number of significant matches.
List
Links to the first 20 matches
Target Databases

The target motifs section lists details on the motif databases that were specifed to search.

Database
The database name.
Number of Motifs
The number of motifs read from the motif database minus the number that had to be discarded due to conflicting ids.
Motifs Matched
The number of motifs that had a match with at least one of the query motifs.

Matches

The matches section list the group of motifs that match each query motif. For each query-target match the following information is given:

Summary Table

The summary gives the important statistics about the motif match.

Name
The name of the matched motif.
Alt. Name
The alternative name of the matched motif.
p-value
The probability that the match occurred by random chance according to the null model.
E-value
The expected number of false positives in the matches up to this point.
q-value
The minimum False Discovery Rate required to include the match.
Overlap
The number of letters that overlaped in the optimal alignment.
Offset
The offset of the query motif to the matched motif in the optimal alignment.
Orientation
The orientation of the matched motif that gave the optimal alignment. A value of "normal" means that the matched motif is as it appears in the database otherwise the matched motif has been reverse complemented.
Alignment

The image shows the alignment of the two motifs. The matched motif is shown on the top and the query motif is shown on the bottom.

Create custom LOGO

By clicking the link "Create custom LOGO ↧" a form to make custom logos will be displayed. The download button can then be clicked to generate a motif matching the selected specifications.

Image Type
Two image formats, png and eps, are avaliable. The pixel based portable network graphic (png) format is commonly used on the Internet and the Encapsulated PostScript (eps) format is more suitable for publications that might require scaling.
Error bars
Toggle error bars indicating the confidence of a motif based on the number of sites used in its creation.
SSC
Toggle adding pseudocounts for Small Sample Correction.
Flip
Toggle a full reverse complement of the alignment.
Width
Specify the width of the generated motif.
Height
Specify the height of the generated motif.