Category ID Category Name #Genes Category #Genes Assigned #Genes Expected #Genes Enriched p-value Corrected p-value GO:0007049 cell cycle 642 39.0 9.1 +29.9 8.5E-15 <0.001 GO:0051301 cell division 319 26.0 4.5 +21.5 5.5E-13 <0.001 GO:0022403 cell cycle phase 334 26.0 4.7 +21.3 1.6E-12 <0.001 GO:0000279 M phase 295 24.0 4.2 +19.8 4.8E-12 <0.001 GO:0022402 cell cycle process 388 26.0 5.5 +20.5 4.6E-11 <0.001 GO:0000278 mitotic cell cycle 269 21.0 3.8 +17.2 2.4E-10 <0.001 GO:0007067 mitosis 206 17.0 2.9 +14.1 5.8E-9 <0.001 GO:0000280 nuclear division 206 17.0 2.9 +14.1 5.8E-9 <0.001 GO:0000087 M phase of mitotic cell cycle 208 17.0 3.0 +14.0 6.7E-9 <0.001 GO:0048285 organelle fission 210 17.0 3.0 +14.0 7.7E-9 <0.001 GO:0000775 chromosome, centromeric region 75 10.0 1.1 +8.9 9.9E-8 <0.001 GO:0006996 organelle organization 929 32.0 13.2 +18.8 2.6E-6 <0.001 GO:0000910 cytokinesis 20 5.0 0.3 +4.7 7.1E-6 0.002 GO:0007126 meiosis 95 9.0 1.3 +7.7 8.0E-6 0.002 GO:0051327 M phase of meiotic cell cycle 95 9.0 1.3 +7.7 8.0E-6 0.002 GO:0051321 meiotic cell cycle 96 9.0 1.4 +7.6 8.7E-6 0.002 GO:0006261 DNA-dependent DNA replication 35 6.0 0.5 +5.5 8.7E-6 0.002 GO:0005819 spindle 47 6.0 0.7 +5.3 5.0E-5 0.026 GO:0007059 chromosome segregation 50 6.0 0.7 +5.3 7.2E-5 0.030 GO:0000228 nuclear chromosome 112 8.0 1.6 +6.4 1.9E-4 0.064 GO:0007346 regulation of mitotic cell cycle 61 6.0 0.9 +5.1 2.2E-4 0.070 GO:0044454 nuclear chromosome part 96 7.0 1.4 +5.6 4.3E-4 0.126 GO:0010564 regulation of cell cycle process 55 5.0 0.8 +4.2 1.1E-3 0.284 GO:0051276 chromosome organization 312 12.0 4.4 +7.6 1.7E-3 0.388 GO:0071103 DNA conformation change 70 5.0 1.0 +4.0 3.1E-3 0.558 GO:0005634 nucleus 8450 139.0 119.9 +19.1 3.6E-3 0.580 GO:0005856 cytoskeleton 793 21.0 11.3 +9.7 4.4E-3 0.644 GO:0016044 membrane organization 243 9.0 3.4 +5.6 7.9E-3 0.796 GO:0044430 cytoskeletal part 487 14.0 6.9 +7.1 9.7E-3 0.858 GO:0005938 cell cortex 93 5.0 1.3 +3.7 0.01 0.868 GO:0005524 ATP binding 1254 28.0 17.8 +10.2 0.01 0.880 GO:0032559 adenyl ribonucleotide binding 1269 28.0 18.0 +10.0 0.01 0.904 GO:0043228 non-membrane-bounded organelle 7234 119.0 102.6 +16.4 0.01 0.906 GO:0043232 intracellular non-membrane-bounded organelle 7234 119.0 102.6 +16.4 0.01 0.906 GO:0016192 vesicle-mediated transport 413 12.0 5.9 +6.1 0.01 0.932 GO:0034984 cellular response to DNA damage stimulus 229 8.0 3.2 +4.8 0.02 0.950 GO:0032555 purine ribonucleotide binding 1550 32.0 22.0 +10.0 0.02 0.960 GO:0032553 ribonucleotide binding 1550 32.0 22.0 +10.0 0.02 0.960 GO:0051726 regulation of cell cycle 149 6.0 2.1 +3.9 0.02 0.964 GO:0006954 inflammatory response 13927 203.0 197.6 +5.4 0.02 0.964 GO:0009611 response to wounding 13927 203.0 197.6 +5.4 0.02 0.964 GO:0042127 regulation of cell proliferation 431 12.0 6.1 +5.9 0.02 0.966 GO:0006952 defense response 13929 203.0 197.6 +5.4 0.02 0.968 GO:0009605 response to external stimulus 13929 203.0 197.6 +5.4 0.02 0.968 GO:0007166 cell surface receptor linked signal transduction 13933 203.0 197.7 +5.3 0.02 0.972 GO:0006950 response to stress 13936 203.0 197.7 +5.3 0.02 0.972 GO:0065008 regulation of biological quality 13938 203.0 197.8 +5.2 0.02 0.976 GO:0007010 cytoskeleton organization 293 9.0 4.2 +4.8 0.02 0.980 GO:0007165 signal transduction 13946 203.0 197.9 +5.1 0.02 0.980 GO:0019899 enzyme binding 157 6.0 2.2 +3.8 0.02 0.980 GO:0006281 DNA repair 201 7.0 2.9 +4.1 0.02 0.980 GO:0007154 cell communication 13947 203.0 197.9 +5.1 0.02 0.980 GO:0005506 iron ion binding 249 8.0 3.5 +4.5 0.03 0.982 GO:0044422 organelle part 13951 203.0 197.9 +5.1 0.03 0.984 GO:0044446 intracellular organelle part 13951 203.0 197.9 +5.1 0.03 0.984 GO:0044428 nuclear part 772 18.0 11.0 +7.0 0.03 0.984 GO:0048522 positive regulation of cellular process 1057 23.0 15.0 +8.0 0.03 0.984 GO:0007155 cell adhesion 501 13.0 7.1 +5.9 0.03 0.984 GO:0015630 microtubule cytoskeleton 299 9.0 4.2 +4.8 0.03 0.986 GO:0044260 cellular macromolecule metabolic process 8621 136.0 122.3 +13.7 0.03 0.990 GO:0006974 response to DNA damage stimulus 257 8.0 3.6 +4.4 0.03 0.992 GO:0044444 cytoplasmic part 13967 203.0 198.2 +4.8 0.03 0.992 GO:0006260 DNA replication 6651 108.0 94.4 +13.6 0.03 0.992 GO:0050794 regulation of cellular process 13982 203.0 198.4 +4.6 0.04 0.994 GO:0005515 protein binding 13983 203.0 198.4 +4.6 0.04 0.994 GO:0050789 regulation of biological process 13985 203.0 198.4 +4.6 0.04 0.994 GO:0006897 endocytosis 178 6.0 2.5 +3.5 0.04 0.996 GO:0010324 membrane invagination 178 6.0 2.5 +3.5 0.04 0.996 GO:0006259 DNA metabolic process 6780 109.0 96.2 +12.8 0.04 0.996 GO:0005737 cytoplasm 13995 203.0 198.6 +4.4 0.04 0.996 GO:0006807 nitrogen compound metabolic process 8076 127.0 114.6 +12.4 0.05 0.998 GO:0034645 cellular macromolecule biosynthetic process 7723 122.0 109.6 +12.4 0.05 0.998 GO:0006139 nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 7938 125.0 112.6 +12.4 0.05 0.998 GO:0009059 macromolecule biosynthetic process 7725 122.0 109.6 +12.4 0.05 0.998 GO:0005694 chromosome 6738 108.0 95.6 +12.4 0.05 0.998 GO:0008284 positive regulation of cell proliferation 233 7.0 3.3 +3.7 0.05 0.998 GO:0048518 positive regulation of biological process 1186 24.0 16.8 +7.2 0.05 0.998 GO:0044427 chromosomal part 6704 107.0 95.1 +11.9 0.05 1.000 GO:0016301 kinase activity 727 16.0 10.3 +5.7 0.05 1.000 GO:0043231 intracellular membrane-bounded organelle 14024 203.0 199.0 +4.0 0.06 1.000 GO:0043227 membrane-bounded organelle 14024 203.0 199.0 +4.0 0.06 1.000 GO:0043229 intracellular organelle 14029 203.0 199.1 +3.9 0.06 1.000 GO:0007264 small GTPase mediated signal transduction 351 9.0 5.0 +4.0 0.06 1.000 GO:0030695 GTPase regulator activity 300 8.0 4.3 +3.7 0.06 1.000 GO:0001701 in utero embryonic development 250 7.0 3.5 +3.5 0.07 1.000 GO:0043170 macromolecule metabolic process 8822 136.0 125.2 +10.8 0.07 1.000 GO:0044424 intracellular part 14042 203.0 199.2 +3.8 0.07 1.000 GO:0060589 nucleoside-triphosphatase regulator activity 305 8.0 4.3 +3.7 0.07 1.000 GO:0003677 DNA binding 7268 114.0 103.1 +10.9 0.07 1.000 GO:0005622 intracellular 14047 203.0 199.3 +3.7 0.07 1.000 GO:0009058 biosynthetic process 8058 125.0 114.3 +10.7 0.07 1.000 GO:0016563 transcription activator activity 209 6.0 3.0 +3.0 0.08 1.000 GO:0005096 GTPase activator activity 162 5.0 2.3 +2.7 0.08 1.000 GO:0007017 microtubule-based process 163 5.0 2.3 +2.7 0.08 1.000 GO:0044249 cellular biosynthetic process 8033 124.0 114.0 +10.0 0.09 1.000 GO:0044464 cell part 14067 203.0 199.6 +3.4 0.09 1.000 GO:0044237 cellular metabolic process 9195 140.0 130.5 +9.5 0.09 1.000 GO:0015629 actin cytoskeleton 169 5.0 2.4 +2.6 0.09 1.000 GO:0045934 negative regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 326 8.0 4.6 +3.4 0.09 1.000 GO:0051172 negative regulation of nitrogen compound metabolic process 328 8.0 4.7 +3.3 0.10 1.000 GO:0002684 positive regulation of immune system process 172 5.0 2.4 +2.6 0.10 1.000 GO:0005083 small GTPase regulator activity 172 5.0 2.4 +2.6 0.10 1.000 GO:0017111 nucleoside-triphosphatase activity 502 11.0 7.1 +3.9 0.10 1.000 GO:0019219 regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 7445 115.0 105.6 +9.4 0.11 1.000 GO:0016772 transferase activity, transferring phosphorus-containing groups 6953 108.0 98.7 +9.3 0.11 1.000 GO:0051171 regulation of nitrogen compound metabolic process 7450 115.0 105.7 +9.3 0.11 1.000 GO:0043009 chordate embryonic development 397 9.0 5.6 +3.4 0.11 1.000 GO:0042623 ATPase activity, coupled 180 5.0 2.6 +2.4 0.11 1.000 GO:0009790 embryonic development 6833 106.0 97.0 +9.0 0.11 1.000 GO:0008283 cell proliferation 6839 106.0 97.0 +9.0 0.12 1.000 GO:0048519 negative regulation of biological process 7050 109.0 100.0 +9.0 0.12 1.000 GO:0009792 embryonic development ending in birth or egg hatching 401 9.0 5.7 +3.3 0.12 1.000 GO:0000166 nucleotide binding 7406 114.0 105.1 +8.9 0.12 1.000 GO:0003676 nucleic acid binding 7620 117.0 108.1 +8.9 0.12 1.000 GO:0060255 regulation of macromolecule metabolic process 7561 116.0 107.3 +8.7 0.12 1.000 GO:0080090 regulation of primary metabolic process 7564 116.0 107.3 +8.7 0.12 1.000 GO:0016491 oxidoreductase activity 6865 106.0 97.4 +8.6 0.13 1.000 GO:0030554 adenyl nucleotide binding 7151 110.0 101.5 +8.5 0.13 1.000 GO:0001883 purine nucleoside binding 7151 110.0 101.5 +8.5 0.13 1.000 GO:0016462 pyrophosphatase activity 527 11.0 7.5 +3.5 0.13 1.000 GO:0048523 negative regulation of cellular process 7013 108.0 99.5 +8.5 0.13 1.000 GO:0001882 nucleoside binding 7155 110.0 101.5 +8.5 0.13 1.000 GO:0008092 cytoskeletal protein binding 354 8.0 5.0 +3.0 0.13 1.000 GO:0016817 hydrolase activity, acting on acid anhydrides 530 11.0 7.5 +3.5 0.13 1.000 GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides 530 11.0 7.5 +3.5 0.13 1.000 GO:0031323 regulation of cellular metabolic process 7592 116.0 107.7 +8.3 0.14 1.000 GO:0044238 primary metabolic process 9236 139.0 131.0 +8.0 0.14 1.000 GO:0043412 macromolecule modification 7101 109.0 100.8 +8.2 0.14 1.000 GO:0048869 cellular developmental process 7247 111.0 102.8 +8.2 0.14 1.000 GO:0046649 lymphocyte activation 6685 103.0 94.9 +8.1 0.14 1.000 GO:0048856 anatomical structure development 7391 113.0 104.9 +8.1 0.14 1.000 GO:0031324 negative regulation of cellular metabolic process 6760 104.0 95.9 +8.1 0.14 1.000 GO:0010556 regulation of macromolecule biosynthetic process 7466 114.0 105.9 +8.1 0.14 1.000 GO:0006357 regulation of transcription from RNA polymerase II promoter 539 11.0 7.6 +3.4 0.15 1.000 GO:0051128 regulation of cellular component organization 250 6.0 3.5 +2.5 0.15 1.000 GO:0033554 cellular response to stress 6768 104.0 96.0 +8.0 0.15 1.000 GO:0045321 leukocyte activation 6699 103.0 95.1 +7.9 0.15 1.000 GO:0001775 cell activation 6704 103.0 95.1 +7.9 0.15 1.000 GO:0009892 negative regulation of metabolic process 6778 104.0 96.2 +7.8 0.15 1.000 GO:0045893 positive regulation of transcription, DNA-dependent 367 8.0 5.2 +2.8 0.15 1.000 GO:0043687 post-translational protein modification 6991 107.0 99.2 +7.8 0.15 1.000 GO:0032879 regulation of localization 310 7.0 4.4 +2.6 0.15 1.000 GO:0032943 mononuclear cell proliferation 6643 102.0 94.3 +7.7 0.15 1.000 GO:0046651 lymphocyte proliferation 6643 102.0 94.3 +7.7 0.15 1.000 GO:0048583 regulation of response to stimulus 254 6.0 3.6 +2.4 0.15 1.000 GO:0051254 positive regulation of RNA metabolic process 368 8.0 5.2 +2.8 0.15 1.000 GO:0070661 leukocyte proliferation 6644 102.0 94.3 +7.7 0.15 1.000 GO:0003779 actin binding 255 6.0 3.6 +2.4 0.16 1.000 GO:0006464 protein modification process 7069 108.0 100.3 +7.7 0.16 1.000 GO:0048513 organ development 7214 110.0 102.4 +7.6 0.16 1.000 GO:0030154 cell differentiation 7216 110.0 102.4 +7.6 0.16 1.000 GO:0055114 oxidation reduction 6865 105.0 97.4 +7.6 0.16 1.000 GO:0007242 intracellular signaling cascade 7008 107.0 99.4 +7.6 0.16 1.000 GO:0031326 regulation of cellular biosynthetic process 7502 114.0 106.4 +7.6 0.16 1.000 GO:0042110 T cell activation 6658 102.0 94.5 +7.5 0.16 1.000 GO:0009889 regulation of biosynthetic process 7503 114.0 106.5 +7.5 0.16 1.000 GO:0006350 transcription 7433 113.0 105.5 +7.5 0.16 1.000 GO:0034621 cellular macromolecular complex subunit organization 203 5.0 2.9 +2.1 0.16 1.000 GO:0019222 regulation of metabolic process 7648 116.0 108.5 +7.5 0.16 1.000 GO:0017076 purine nucleotide binding 7295 111.0 103.5 +7.5 0.16 1.000 GO:0016477 cell migration 259 6.0 3.7 +2.3 0.16 1.000 GO:0007517 muscle organ development 204 5.0 2.9 +2.1 0.16 1.000 GO:0005667 transcription factor complex 205 5.0 2.9 +2.1 0.17 1.000 GO:0009986 cell surface 205 5.0 2.9 +2.1 0.17 1.000 GO:0048037 cofactor binding 6672 102.0 94.7 +7.3 0.17 1.000 GO:0008047 enzyme activator activity 206 5.0 2.9 +2.1 0.17 1.000 GO:0051716 cellular response to stimulus 6818 104.0 96.7 +7.3 0.17 1.000 GO:0048514 blood vessel morphogenesis 208 5.0 3.0 +2.0 0.17 1.000 GO:0045449 regulation of transcription 7401 112.0 105.0 +7.0 0.18 1.000 GO:0030097 hemopoiesis 6698 102.0 95.0 +7.0 0.18 1.000 GO:0042098 T cell proliferation 6629 101.0 94.1 +6.9 0.18 1.000 GO:0045944 positive regulation of transcription from RNA polymerase II promoter 326 7.0 4.6 +2.4 0.18 1.000 GO:0006468 protein amino acid phosphorylation 6846 104.0 97.1 +6.9 0.18 1.000 GO:0007275 multicellular organismal development 7551 114.0 107.1 +6.9 0.19 1.000 GO:0050863 regulation of T cell activation 6637 101.0 94.2 +6.8 0.19 1.000 GO:0006366 transcription from RNA polymerase II promoter 569 11.0 8.1 +2.9 0.19 1.000 GO:0050793 regulation of developmental process 6778 103.0 96.2 +6.8 0.19 1.000 GO:0048534 hemopoietic or lymphoid organ development 6709 102.0 95.2 +6.8 0.19 1.000 GO:0010557 positive regulation of macromolecule biosynthetic process 448 9.0 6.4 +2.6 0.19 1.000 GO:0048731 system development 7344 111.0 104.2 +6.8 0.19 1.000 GO:0002520 immune system development 6714 102.0 95.3 +6.7 0.19 1.000 GO:0051249 regulation of lymphocyte activation 6645 101.0 94.3 +6.7 0.19 1.000 GO:0016740 transferase activity 7281 110.0 103.3 +6.7 0.19 1.000 GO:0002694 regulation of leukocyte activation 6649 101.0 94.3 +6.7 0.19 1.000 GO:0009968 negative regulation of signal transduction 6650 101.0 94.4 +6.6 0.19 1.000 GO:0050865 regulation of cell activation 6650 101.0 94.4 +6.6 0.19 1.000 GO:0010648 negative regulation of cell communication 6654 101.0 94.4 +6.6 0.20 1.000 GO:0016887 ATPase activity 217 5.0 3.1 +1.9 0.20 1.000 GO:0010558 negative regulation of macromolecule biosynthetic process 334 7.0 4.7 +2.3 0.20 1.000 GO:0010604 positive regulation of macromolecule metabolic process 516 10.0 7.3 +2.7 0.20 1.000 GO:0004672 protein kinase activity 517 10.0 7.3 +2.7 0.20 1.000 GO:0043933 macromolecular complex subunit organization 278 6.0 3.9 +2.1 0.20 1.000 GO:0031325 positive regulation of cellular metabolic process 521 10.0 7.4 +2.6 0.21 1.000 GO:0006796 phosphate metabolic process 6966 105.0 98.8 +6.2 0.21 1.000 GO:0006793 phosphorus metabolic process 6966 105.0 98.8 +6.2 0.21 1.000 GO:0031328 positive regulation of cellular biosynthetic process 464 9.0 6.6 +2.4 0.21 1.000 GO:0009891 positive regulation of biosynthetic process 465 9.0 6.6 +2.4 0.22 1.000 GO:0016310 phosphorylation 6903 104.0 97.9 +6.1 0.22 1.000 GO:0031327 negative regulation of cellular biosynthetic process 344 7.0 4.9 +2.1 0.22 1.000 GO:0031981 nuclear lumen 466 9.0 6.6 +2.4 0.22 1.000 GO:0002682 regulation of immune system process 6694 101.0 95.0 +6.0 0.22 1.000 GO:0051098 regulation of binding 6624 100.0 94.0 +6.0 0.22 1.000 GO:0010467 gene expression 7824 117.0 111.0 +6.0 0.22 1.000 GO:0010605 negative regulation of macromolecule metabolic process 406 8.0 5.8 +2.2 0.22 1.000 GO:0006916 anti-apoptosis 6628 100.0 94.0 +6.0 0.22 1.000 GO:0009890 negative regulation of biosynthetic process 346 7.0 4.9 +2.1 0.22 1.000 GO:0010468 regulation of gene expression 7477 112.0 106.1 +5.9 0.22 1.000 GO:0048870 cell motility 287 6.0 4.1 +1.9 0.22 1.000 GO:0051674 localization of cell 287 6.0 4.1 +1.9 0.22 1.000 GO:0030098 lymphocyte differentiation 6636 100.0 94.2 +5.8 0.23 1.000 GO:0045941 positive regulation of transcription 409 8.0 5.8 +2.2 0.23 1.000 GO:0004872 receptor activity 1110 19.0 15.7 +3.3 0.23 1.000 GO:0050662 coenzyme binding 6643 100.0 94.3 +5.7 0.23 1.000 GO:0045595 regulation of cell differentiation 6715 101.0 95.3 +5.7 0.23 1.000 GO:0048646 anatomical structure formation involved in morphogenesis 6716 101.0 95.3 +5.7 0.23 1.000 GO:0002521 leukocyte differentiation 6651 100.0 94.4 +5.6 0.23 1.000 GO:0010628 positive regulation of gene expression 419 8.0 5.9 +2.1 0.25 1.000 GO:0016667 oxidoreductase activity, acting on sulfur group of donors 6603 99.0 93.7 +5.3 0.25 1.000 GO:0005783 endoplasmic reticulum 673 12.0 9.5 +2.5 0.25 1.000 GO:0009966 regulation of signal transduction 6818 102.0 96.7 +5.3 0.25 1.000 GO:0042221 response to chemical stimulus 6820 102.0 96.8 +5.2 0.25 1.000 GO:0048729 tissue morphogenesis 6681 100.0 94.8 +5.2 0.25 1.000 GO:0009893 positive regulation of metabolic process 549 10.0 7.8 +2.2 0.25 1.000 GO:0050660 FAD binding 6612 99.0 93.8 +5.2 0.25 1.000 GO:0050868 negative regulation of T cell activation 6612 99.0 93.8 +5.2 0.25 1.000 GO:0002695 negative regulation of leukocyte activation 6613 99.0 93.8 +5.2 0.25 1.000 GO:0050866 negative regulation of cell activation 6613 99.0 93.8 +5.2 0.25 1.000 GO:0051250 negative regulation of lymphocyte activation 6613 99.0 93.8 +5.2 0.25 1.000 GO:0043066 negative regulation of apoptosis 6685 100.0 94.9 +5.1 0.26 1.000 GO:0051101 regulation of DNA binding 6617 99.0 93.9 +5.1 0.26 1.000 GO:0043069 negative regulation of programmed cell death 6688 100.0 94.9 +5.1 0.26 1.000 GO:0060548 negative regulation of cell death 6688 100.0 94.9 +5.1 0.26 1.000 GO:0002683 negative regulation of immune system process 6618 99.0 93.9 +5.1 0.26 1.000 GO:0045454 cell redox homeostasis 6619 99.0 93.9 +5.1 0.26 1.000 GO:0030217 T cell differentiation 6620 99.0 93.9 +5.1 0.26 1.000 GO:0010033 response to organic substance 6694 100.0 95.0 +5.0 0.26 1.000 GO:0016773 phosphotransferase activity, alcohol group as acceptor 618 11.0 8.8 +2.2 0.26 1.000 GO:0035295 tube development 243 5.0 3.4 +1.6 0.26 1.000 GO:0048872 homeostasis of number of cells 6627 99.0 94.0 +5.0 0.26 1.000 GO:0045935 positive regulation of nucleobase, nucleoside, nucleotide and nucleic acid metabolic process 429 8.0 6.1 +1.9 0.27 1.000 GO:0009888 tissue development 6845 102.0 97.1 +4.9 0.27 1.000 GO:0070887 cellular response to chemical stimulus 6635 99.0 94.1 +4.9 0.27 1.000 GO:0016779 nucleotidyltransferase activity 6638 99.0 94.2 +4.8 0.27 1.000 GO:0042592 homeostatic process 6779 101.0 96.2 +4.8 0.27 1.000 GO:0048598 embryonic morphogenesis 6709 100.0 95.2 +4.8 0.27 1.000 GO:0019725 cellular homeostasis 6711 100.0 95.2 +4.8 0.27 1.000 GO:0006915 apoptosis 6922 103.0 98.2 +4.8 0.27 1.000 GO:0010646 regulation of cell communication 6853 102.0 97.2 +4.8 0.27 1.000 GO:0012501 programmed cell death 6926 103.0 98.3 +4.7 0.28 1.000 GO:0000165 MAPKKK cascade 6646 99.0 94.3 +4.7 0.28 1.000 GO:0042981 regulation of apoptosis 6787 101.0 96.3 +4.7 0.28 1.000 GO:0045596 negative regulation of cell differentiation 6647 99.0 94.3 +4.7 0.28 1.000 GO:0006928 cellular component movement 372 7.0 5.3 +1.7 0.28 1.000 GO:0031966 mitochondrial membrane 310 6.0 4.4 +1.6 0.28 1.000 GO:0043067 regulation of programmed cell death 6790 101.0 96.3 +4.7 0.28 1.000 GO:0010941 regulation of cell death 6792 101.0 96.4 +4.6 0.28 1.000 GO:0051173 positive regulation of nitrogen compound metabolic process 438 8.0 6.2 +1.8 0.28 1.000 GO:0001568 blood vessel development 251 5.0 3.6 +1.4 0.28 1.000 GO:0045730 respiratory burst 6589 98.0 93.5 +4.5 0.29 1.000 GO:0002536 respiratory burst during acute inflammatory response 6589 98.0 93.5 +4.5 0.29 1.000 GO:0003964 RNA-directed DNA polymerase activity 6589 98.0 93.5 +4.5 0.29 1.000 GO:0010671 negative regulation of oxygen and reactive oxygen species metabolic process 6589 98.0 93.5 +4.5 0.29 1.000 GO:0031664 regulation of lipopolysaccharide-mediated signaling pathway 6589 98.0 93.5 +4.5 0.29 1.000 GO:0031665 negative regulation of lipopolysaccharide-mediated signaling pathway 6589 98.0 93.5 +4.5 0.29 1.000 GO:0002679 respiratory burst during defense response 6589 98.0 93.5 +4.5 0.29 1.000 GO:0010310 regulation of hydrogen peroxide metabolic process 6589 98.0 93.5 +4.5 0.29 1.000 GO:0003721 telomeric template RNA reverse transcriptase activity 6589 98.0 93.5 +4.5 0.29 1.000 GO:0003720 telomerase activity 6589 98.0 93.5 +4.5 0.29 1.000 GO:0080010 regulation of oxygen and reactive oxygen species metabolic process 6589 98.0 93.5 +4.5 0.29 1.000 GO:0051920 peroxiredoxin activity 6589 98.0 93.5 +4.5 0.29 1.000 GO:0008379 thioredoxin peroxidase activity 6589 98.0 93.5 +4.5 0.29 1.000 GO:0004791 thioredoxin-disulfide reductase activity 6590 98.0 93.5 +4.5 0.29 1.000 GO:0006278 RNA-dependent DNA replication 6590 98.0 93.5 +4.5 0.29 1.000 GO:0051093 negative regulation of developmental process 6661 99.0 94.5 +4.5 0.29 1.000 GO:0008219 cell death 6942 103.0 98.5 +4.5 0.29 1.000 GO:0002532 production of molecular mediator of acute inflammatory response 6591 98.0 93.5 +4.5 0.29 1.000 GO:0016668 oxidoreductase activity, acting on sulfur group of donors, NAD or NADP as acceptor 6591 98.0 93.5 +4.5 0.29 1.000 GO:0070301 cellular response to hydrogen peroxide 6592 98.0 93.5 +4.5 0.29 1.000 GO:0034614 cellular response to reactive oxygen species 6592 98.0 93.5 +4.5 0.29 1.000 GO:0032088 negative regulation of NF-kappaB transcription factor activity 6592 98.0 93.5 +4.5 0.29 1.000 GO:0042744 hydrogen peroxide catabolic process 6592 98.0 93.5 +4.5 0.29 1.000 GO:0042743 hydrogen peroxide metabolic process 6593 98.0 93.5 +4.5 0.29 1.000 GO:0034599 cellular response to oxidative stress 6593 98.0 93.5 +4.5 0.29 1.000 GO:0045581 negative regulation of T cell differentiation 6593 98.0 93.5 +4.5 0.29 1.000 GO:0031663 lipopolysaccharide-mediated signaling pathway 6593 98.0 93.5 +4.5 0.29 1.000 GO:0045620 negative regulation of lymphocyte differentiation 6593 98.0 93.5 +4.5 0.29 1.000 GO:0042542 response to hydrogen peroxide 6594 98.0 93.6 +4.4 0.29 1.000 GO:0000781 chromosome, telomeric region 6594 98.0 93.6 +4.4 0.29 1.000 GO:0000302 response to reactive oxygen species 6595 98.0 93.6 +4.4 0.29 1.000 GO:0043433 negative regulation of transcription factor activity 6595 98.0 93.6 +4.4 0.29 1.000 GO:0090048 negative regulation of transcription regulator activity 6595 98.0 93.6 +4.4 0.29 1.000 GO:0050661 NADP or NADPH binding 6596 98.0 93.6 +4.4 0.29 1.000 GO:0043392 negative regulation of DNA binding 6596 98.0 93.6 +4.4 0.29 1.000 GO:0048538 thymus development 6596 98.0 93.6 +4.4 0.29 1.000 GO:0051100 negative regulation of binding 6597 98.0 93.6 +4.4 0.29 1.000 GO:0016684 oxidoreductase activity, acting on peroxide as acceptor 6597 98.0 93.6 +4.4 0.29 1.000 GO:0048332 mesoderm morphogenesis 6597 98.0 93.6 +4.4 0.29 1.000 GO:0004601 peroxidase activity 6597 98.0 93.6 +4.4 0.29 1.000 GO:0001704 formation of primary germ layer 6597 98.0 93.6 +4.4 0.29 1.000 GO:0001707 mesoderm formation 6597 98.0 93.6 +4.4 0.29 1.000 GO:0009607 response to biotic stimulus 6668 99.0 94.6 +4.4 0.29 1.000 GO:0000187 activation of MAPK activity 6600 98.0 93.6 +4.4 0.29 1.000 GO:0034061 DNA polymerase activity 6601 98.0 93.7 +4.3 0.29 1.000 GO:0043406 positive regulation of MAP kinase activity 6602 98.0 93.7 +4.3 0.29 1.000 GO:0006800 oxygen and reactive oxygen species metabolic process 6603 98.0 93.7 +4.3 0.29 1.000 GO:0032496 response to lipopolysaccharide 6603 98.0 93.7 +4.3 0.29 1.000 GO:0045580 regulation of T cell differentiation 6604 98.0 93.7 +4.3 0.30 1.000 GO:0008430 selenium binding 6604 98.0 93.7 +4.3 0.30 1.000 GO:0002237 response to molecule of bacterial origin 6605 98.0 93.7 +4.3 0.30 1.000 GO:0044093 positive regulation of molecular function 6676 99.0 94.7 +4.3 0.30 1.000 GO:0006979 response to oxidative stress 6606 98.0 93.7 +4.3 0.30 1.000 GO:0045619 regulation of lymphocyte differentiation 6606 98.0 93.7 +4.3 0.30 1.000 GO:0007498 mesoderm development 6607 98.0 93.7 +4.3 0.30 1.000 GO:0016651 oxidoreductase activity, acting on NADH or NADPH 6608 98.0 93.8 +4.2 0.30 1.000 GO:0001944 vasculature development 256 5.0 3.6 +1.4 0.30 1.000 GO:0051090 regulation of transcription factor activity 6609 98.0 93.8 +4.2 0.30 1.000 GO:0090046 regulation of transcription regulator activity 6609 98.0 93.8 +4.2 0.30 1.000 GO:0007369 gastrulation 6610 98.0 93.8 +4.2 0.30 1.000 GO:0042325 regulation of phosphorylation 6682 99.0 94.8 +4.2 0.30 1.000 GO:0043405 regulation of MAP kinase activity 6612 98.0 93.8 +4.2 0.30 1.000 GO:0045892 negative regulation of transcription, DNA-dependent 257 5.0 3.6 +1.4 0.30 1.000 GO:0019220 regulation of phosphate metabolic process 6685 99.0 94.9 +4.1 0.30 1.000 GO:0051174 regulation of phosphorus metabolic process 6685 99.0 94.9 +4.1 0.30 1.000 GO:0007243 protein kinase cascade 6686 99.0 94.9 +4.1 0.30 1.000 GO:0002526 acute inflammatory response 6616 98.0 93.9 +4.1 0.30 1.000 GO:0004674 protein serine/threonine kinase activity 384 7.0 5.4 +1.6 0.30 1.000 GO:0051253 negative regulation of RNA metabolic process 258 5.0 3.7 +1.3 0.30 1.000 GO:0005743 mitochondrial inner membrane 259 5.0 3.7 +1.3 0.31 1.000 GO:0045860 positive regulation of protein kinase activity 6622 98.0 94.0 +4.0 0.31 1.000 GO:0033674 positive regulation of kinase activity 6623 98.0 94.0 +4.0 0.31 1.000 GO:0051347 positive regulation of transferase activity 6623 98.0 94.0 +4.0 0.31 1.000 GO:0006955 immune response 6764 100.0 96.0 +4.0 0.31 1.000 GO:0005740 mitochondrial envelope 323 6.0 4.6 +1.4 0.31 1.000 GO:0043234 protein complex 12257 177.0 173.9 +3.1 0.31 1.000 GO:0044451 nucleoplasm part 324 6.0 4.6 +1.4 0.31 1.000 GO:0044267 cellular protein metabolic process 7473 110.0 106.0 +4.0 0.31 1.000 GO:0065009 regulation of molecular function 6770 100.0 96.1 +3.9 0.31 1.000 GO:0045087 innate immune response 6631 98.0 94.1 +3.9 0.31 1.000 GO:0044092 negative regulation of molecular function 6632 98.0 94.1 +3.9 0.32 1.000 GO:0009617 response to bacterium 6634 98.0 94.1 +3.9 0.32 1.000 GO:0002252 immune effector process 6639 98.0 94.2 +3.8 0.32 1.000 GO:0009653 anatomical structure morphogenesis 6992 103.0 99.2 +3.8 0.32 1.000 GO:0045859 regulation of protein kinase activity 6642 98.0 94.2 +3.8 0.32 1.000 GO:0043549 regulation of kinase activity 6643 98.0 94.3 +3.7 0.32 1.000 GO:0051707 response to other organism 6643 98.0 94.3 +3.7 0.32 1.000 GO:0051338 regulation of transferase activity 6644 98.0 94.3 +3.7 0.32 1.000 GO:0006810 transport 12344 178.0 175.1 +2.9 0.33 1.000 GO:0051234 establishment of localization 12345 178.0 175.2 +2.8 0.33 1.000 GO:0042995 cell projection 12129 175.0 172.1 +2.9 0.33 1.000 GO:0043085 positive regulation of catalytic activity 6659 98.0 94.5 +3.5 0.33 1.000 GO:0004871 signal transducer activity 1330 21.0 18.9 +2.1 0.34 1.000 GO:0070013 intracellular organelle lumen 529 9.0 7.5 +1.5 0.34 1.000 GO:0044425 membrane part 12574 181.0 178.4 +2.6 0.34 1.000 GO:0019866 organelle inner membrane 271 5.0 3.8 +1.2 0.34 1.000 GO:0043233 organelle lumen 531 9.0 7.5 +1.5 0.34 1.000 GO:0000902 cell morphogenesis 339 6.0 4.8 +1.2 0.35 1.000 GO:0051239 regulation of multicellular organismal process 6829 100.0 96.9 +3.1 0.36 1.000 GO:0008289 lipid binding 279 5.0 4.0 +1.0 0.36 1.000 GO:0043005 neuron projection 12093 174.0 171.6 +2.4 0.36 1.000 GO:0005829 cytosol 6703 98.0 95.1 +2.9 0.37 1.000 GO:0003723 RNA binding 6854 100.0 97.3 +2.7 0.38 1.000 GO:0009887 organ morphogenesis 6856 100.0 97.3 +2.7 0.38 1.000 GO:0030529 ribonucleoprotein complex 6787 99.0 96.3 +2.7 0.38 1.000 GO:0044248 cellular catabolic process 7002 102.0 99.4 +2.6 0.38 1.000 GO:0044262 cellular carbohydrate metabolic process 288 5.0 4.1 +0.9 0.39 1.000 GO:0005739 mitochondrion 7223 105.0 102.5 +2.5 0.39 1.000 GO:0007267 cell-cell signaling 12118 174.0 171.9 +2.1 0.39 1.000 GO:0016020 membrane 12694 182.0 180.1 +1.9 0.39 1.000 GO:0050790 regulation of catalytic activity 6737 98.0 95.6 +2.4 0.39 1.000 GO:0048699 generation of neurons 423 7.0 6.0 +1.0 0.39 1.000 GO:0044459 plasma membrane part 12195 175.0 173.0 +2.0 0.40 1.000 GO:0005654 nucleoplasm 358 6.0 5.1 +0.9 0.40 1.000 GO:0044429 mitochondrial part 363 6.0 5.2 +0.8 0.41 1.000 GO:0006066 alcohol metabolic process 298 5.0 4.2 +0.8 0.42 1.000 GO:0005802 trans-Golgi network 12072 173.0 171.3 +1.7 0.42 1.000 GO:0051649 establishment of localization in cell 12144 174.0 172.3 +1.7 0.42 1.000 GO:0005794 Golgi apparatus 12145 174.0 172.3 +1.7 0.42 1.000 GO:0032989 cellular component morphogenesis 366 6.0 5.2 +0.8 0.42 1.000 GO:0048471 perinuclear region of cytoplasm 12074 173.0 171.3 +1.7 0.42 1.000 GO:0033555 multicellular organismal response to stress 12076 173.0 171.3 +1.7 0.42 1.000 GO:0043025 cell soma 12077 173.0 171.4 +1.6 0.42 1.000 GO:0051641 cellular localization 12149 174.0 172.4 +1.6 0.42 1.000 GO:0004888 transmembrane receptor activity 642 10.0 9.1 +0.9 0.43 1.000 GO:0005887 integral to plasma membrane 371 6.0 5.3 +0.7 0.43 1.000 GO:0016481 negative regulation of transcription 304 5.0 4.3 +0.7 0.43 1.000 GO:0044431 Golgi apparatus part 12092 173.0 171.6 +1.4 0.44 1.000 GO:0031090 organelle membrane 579 9.0 8.2 +0.8 0.44 1.000 GO:0032940 secretion by cell 12094 173.0 171.6 +1.4 0.44 1.000 GO:0007268 synaptic transmission 12097 173.0 171.6 +1.4 0.44 1.000 GO:0019538 protein metabolic process 7646 110.0 108.5 +1.5 0.44 1.000 GO:0046903 secretion 12099 173.0 171.7 +1.3 0.45 1.000 GO:0032774 RNA biosynthetic process 1068 16.0 15.2 +0.8 0.45 1.000 GO:0019226 transmission of nerve impulse 12104 173.0 171.7 +1.3 0.45 1.000 GO:0030054 cell junction 12108 173.0 171.8 +1.2 0.45 1.000 GO:0031226 intrinsic to plasma membrane 382 6.0 5.4 +0.6 0.46 1.000 GO:0022008 neurogenesis 453 7.0 6.4 +0.6 0.46 1.000 GO:0005886 plasma membrane 12335 176.0 175.0 +1.0 0.47 1.000 GO:0003008 system process 12203 174.0 173.1 +0.9 0.48 1.000 GO:0007217 tachykinin receptor signaling pathway 12066 172.0 171.2 +0.8 0.49 1.000 GO:0017075 syntaxin-1 binding 12066 172.0 171.2 +0.8 0.49 1.000 GO:0019905 syntaxin binding 12067 172.0 171.2 +0.8 0.49 1.000 GO:0070044 synaptobrevin 2-SNAP-25-syntaxin-1a complex 12067 172.0 171.2 +0.8 0.49 1.000 GO:0070032 synaptobrevin 2-SNAP-25-syntaxin-1a-complexin I complex 12067 172.0 171.2 +0.8 0.49 1.000 GO:0031201 SNARE complex 12067 172.0 171.2 +0.8 0.49 1.000 GO:0000149 SNARE binding 12068 172.0 171.2 +0.8 0.49 1.000 GO:0019233 sensory perception of pain 12068 172.0 171.2 +0.8 0.49 1.000 GO:0048265 response to pain 12069 172.0 171.2 +0.8 0.49 1.000 GO:0019717 synaptosome 12069 172.0 171.2 +0.8 0.49 1.000 GO:0050890 cognition 12141 173.0 172.3 +0.7 0.49 1.000 GO:0007269 neurotransmitter secretion 12072 172.0 171.3 +0.7 0.49 1.000 GO:0007218 neuropeptide signaling pathway 12074 172.0 171.3 +0.7 0.49 1.000 GO:0001505 regulation of neurotransmitter levels 12076 172.0 171.3 +0.7 0.50 1.000 GO:0030424 axon 12077 172.0 171.4 +0.6 0.50 1.000 GO:0006836 neurotransmitter transport 12078 172.0 171.4 +0.6 0.50 1.000 GO:0003001 generation of a signal involved in cell-cell signaling 12082 172.0 171.4 +0.6 0.50 1.000 GO:0007186 G-protein coupled receptor protein signaling pathway 12161 173.0 172.6 +0.4 0.51 1.000 GO:0010629 negative regulation of gene expression 334 5.0 4.7 +0.3 0.52 1.000 GO:0016070 RNA metabolic process 1474 21.0 20.9 +0.1 0.53 1.000 GO:0046914 transition metal ion binding 1970 28.0 28.0 0.0 0.53 1.000 GO:0031967 organelle envelope 411 6.0 5.8 +0.2 0.53 1.000 GO:0050877 neurological system process 12179 173.0 172.8 +0.2 0.53 1.000 GO:0031975 envelope 413 6.0 5.9 +0.1 0.53 1.000 GO:0009056 catabolic process 7212 102.0 102.3 -0.3 0.55 1.000 GO:0006396 RNA processing 350 5.0 5.0 0.0 0.56 1.000 GO:0007600 sensory perception 12132 172.0 172.1 -0.1 0.56 1.000 GO:0005624 membrane fraction 12138 172.0 172.2 -0.2 0.56 1.000 GO:0005626 insoluble fraction 12140 172.0 172.3 -0.3 0.57 1.000 GO:0048468 cell development 718 10.0 10.2 -0.2 0.57 1.000 GO:0000267 cell fraction 12147 172.0 172.4 -0.4 0.57 1.000 GO:0006355 regulation of transcription, DNA-dependent 1011 14.0 14.3 -0.3 0.58 1.000 GO:0042180 cellular ketone metabolic process 432 6.0 6.1 -0.1 0.58 1.000 GO:0043565 sequence-specific DNA binding 436 6.0 6.2 -0.2 0.59 1.000 GO:0046872 metal ion binding 3024 42.0 42.9 -0.9 0.59 1.000 GO:0051252 regulation of RNA metabolic process 1025 14.0 14.5 -0.5 0.60 1.000 GO:0000287 magnesium ion binding 371 5.0 5.3 -0.3 0.61 1.000 GO:0043169 cation binding 3052 42.0 43.3 -1.3 0.62 1.000 GO:0030182 neuron differentiation 378 5.0 5.4 -0.4 0.63 1.000 GO:0005975 carbohydrate metabolic process 378 5.0 5.4 -0.4 0.63 1.000 GO:0006351 transcription, DNA-dependent 1062 14.0 15.1 -1.1 0.65 1.000 GO:0043167 ion binding 3095 42.0 43.9 -1.9 0.66 1.000 GO:0005509 calcium ion binding 695 9.0 9.9 -0.9 0.66 1.000 GO:0006811 ion transport 642 8.0 9.1 -1.1 0.70 1.000 GO:0022414 reproductive process 489 6.0 6.9 -0.9 0.70 1.000 GO:0015075 ion transmembrane transporter activity 575 7.0 8.2 -1.2 0.71 1.000 GO:0019752 carboxylic acid metabolic process 420 5.0 6.0 -1.0 0.72 1.000 GO:0043436 oxoacid metabolic process 420 5.0 6.0 -1.0 0.72 1.000 GO:0006082 organic acid metabolic process 421 5.0 6.0 -1.0 0.72 1.000 GO:0008324 cation transmembrane transporter activity 425 5.0 6.0 -1.0 0.72 1.000 GO:0045184 establishment of protein localization 615 7.0 8.7 -1.7 0.77 1.000 GO:0022857 transmembrane transporter activity 708 8.0 10.0 -2.0 0.79 1.000 GO:0003700 transcription factor activity 628 7.0 8.9 -1.9 0.79 1.000 GO:0006812 cation transport 474 5.0 6.7 -1.7 0.81 1.000 GO:0044421 extracellular region part 557 6.0 7.9 -1.9 0.81 1.000 GO:0022891 substrate-specific transmembrane transporter activity 645 7.0 9.2 -2.2 0.81 1.000 GO:0022892 substrate-specific transporter activity 734 8.0 10.4 -2.4 0.82 1.000 GO:0007399 nervous system development 737 8.0 10.5 -2.5 0.83 1.000 GO:0044255 cellular lipid metabolic process 517 5.0 7.3 -2.3 0.86 1.000 GO:0015031 protein transport 608 6.0 8.6 -2.6 0.87 1.000 GO:0008270 zinc ion binding 1579 18.0 22.4 -4.4 0.87 1.000 GO:0008104 protein localization 709 7.0 10.1 -3.1 0.88 1.000 GO:0016788 hydrolase activity, acting on ester bonds 540 5.0 7.7 -2.7 0.89 1.000 GO:0044265 cellular macromolecule catabolic process 549 5.0 7.8 -2.8 0.89 1.000 GO:0016021 integral to membrane 3619 44.0 51.3 -7.3 0.90 1.000 GO:0006629 lipid metabolic process 598 5.0 8.5 -3.5 0.93 1.000 GO:0031224 intrinsic to membrane 3714 44.0 52.7 -8.7 0.93 1.000 GO:0016787 hydrolase activity 1731 18.0 24.6 -6.6 0.94 1.000 GO:0033036 macromolecule localization 824 7.0 11.7 -4.7 0.95 1.000 GO:0006508 proteolysis 752 6.0 10.7 -4.7 0.96 1.000 GO:0030163 protein catabolic process 781 6.0 11.1 -5.1 0.97 1.000 GO:0009057 macromolecule catabolic process 895 7.0 12.7 -5.7 0.97 1.000